Biocompatible 3D Matrix with Antimicrobial Properties.
نویسندگان
چکیده
The aim of this study was to develop, characterize and assess the biological activity of a new regenerative 3D matrix with antimicrobial properties, based on collagen (COLL), hydroxyapatite (HAp), β-cyclodextrin (β-CD) and usnic acid (UA). The prepared 3D matrix was characterized by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Microscopy (FT-IRM), Transmission Electron Microscopy (TEM), and X-ray Diffraction (XRD). In vitro qualitative and quantitative analyses performed on cultured diploid cells demonstrated that the 3D matrix is biocompatible, allowing the normal development and growth of MG-63 osteoblast-like cells and exhibited an antimicrobial effect, especially on the Staphylococcus aureus strain, explained by the particular higher inhibitory activity of usnic acid (UA) against Gram positive bacterial strains. Our data strongly recommend the obtained 3D matrix to be used as a successful alternative for the fabrication of three dimensional (3D) anti-infective regeneration matrix for bone tissue engineering.
منابع مشابه
3D Scaffold Designing based on Conductive/Degradable Tetrapolymeric Nanofibers of PHEMA-co-PNIPAAm-co-PCL/PANI for Bone Tissue Engineering
The hydrophilic, conducting, biocompatible and porous scaffolds were designed using poly(2-hydroxy ethyl methacrylate)-co-poly(N-isopropylacrylamide)-co-poly(ε-caprolactone) (P(HEMA-b-NIPAAm-b-CL))/polyaniline (PANI) for the osteoblast applications. To this end, the PHEMA and P(HEMA-b-NIPAAm) were synthesized via reversible addition of fragmentation chain transfer (RAFT) polymerization, and in ...
متن کاملEngineering a sprayable and elastic hydrogel adhesive with antimicrobial properties for wound healing.
Hydrogel-based bioadhesives have emerged as alternatives for sutureless wound closure, since they can mimic the composition and physicochemical properties of the extracellular matrix. However, they are often associated with poor mechanical properties, low adhesion to native tissues, and lack of antimicrobial properties. Herein, a new sprayable, elastic, and biocompatible composite hydrogel, wit...
متن کاملAntimicrobial Treatment of Polymeric Medical Devices by Silver Nanomaterials and Related Technology
Antimicrobial biocompatible polymers form a group of highly desirable materials in medicinal technology that exhibit interesting thermal and mechanical properties, and high chemical resistance. There are numerous types of polymers with antimicrobial activity or antimicrobial properties conferred through their proper modification. In this review, we focus on the second type of polymers, especial...
متن کاملOriganum vulgare mediated green synthesis of biocompatible gold nanoparticles simultaneously possessing plasmonic, antioxidant and antimicrobial properties
Purpose The leaves and flowering stem of Origanum vulgare contain essential oils, flavonoids, phenolic acids and anthocyanins. We propose a new, simple, one-pot, O. vulgare extract (OVE) mediated green synthesis method of biocompatible gold nanoparticles (AuNPs) possessing improved antioxidant, antimicrobial and plasmonic properties. Materials and methods Different concentrations of OVEs were...
متن کاملPreparation and Rheological Property Evaluation of LDPE/ Zinc Oxide Nanocomposite Films for Food Packaging Application
Nowadays, nanoscale innovations in the forms of pathogen detection, active packaging, antimicrobial packaging and barrier formation are poised to elevate food packaging to new heights. Antimicrobial nanocomposite LDPE films containing ZnO nanoparticles at different concentrations (e.g. 1%, 3%, 5% and 3% nano-ZnO pulse 10% polyethylene grafted maleic anhydride (PE-g-MA), w/w pure LDPE), were p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecules
دوره 21 1 شماره
صفحات -
تاریخ انتشار 2016